FEATURES

FAMILY

DESCRIPTION

Also known as H3_CAEEL, his-2, his-6, his-9, his-13, his-17, his-25, his-27, his-32, his-42, his-45, his-49, his-55, his-59, his-63. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

EXTERNAL LINKS

his-2, his-6, his-9, his-13, his-17, his-25, his-27, his-32, his-42, his-45, his-49, his-55, his-59, his-63

his-2, his-6, his-9, his-13, his-17, his-25, his-27, his-32, his-42, his-45, his-49, his-55, his-59, his-63

Mutations

Mutation(s) distribution

Mutations table