FEATURES

FAMILY

DESCRIPTION

Also known as SCX2_CENSU, SCX2. Beta toxin that binds site-4 of sodium channels (Nav) and reduces peak current (observed on Nav1.6/SCN8A (IC(50)=307 nM)), shifts the voltage of activation toward more negative potentials (observed on Nav1.6, Nav1.1 (weak), Nav1.2 (weak), and Nav1.7 (weak)), and induces resurgent currents at negative voltages following brief and strong depolarizations (observed on Nav1.6, Nav1.1 (weak), and Nav1.7 (weak)) (PubMed:22200496). A reduction of peak current of Nav1.5/SCN7A has been observed in another study (IC(50)=35-40 nM) (PubMed:22251893). This toxin is only active on mammals (PubMed:17544584). It has been shown to bind phospholipids (PubMed:15632158).

EXTERNAL LINKS

SCX2

Mutations

Mutation(s) distribution

Mutations table