FEATURES

FAMILY

DESCRIPTION

Also known as GSTP1_HUMAN, GSTP1, FAEES3, GST3. Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GSTP1

Glutathione S-transferase P

GSTP1

Molecular Synopsis