FEATURES

FAMILY

DESCRIPTION

Also known as F16P1_HUMAN, FBP1, FBP. Catalyzes the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FBP1

Fructose-1, 6-bisphosphatase 1

FBP1

Molecular Synopsis