FEATURES

FAMILY

DESCRIPTION

Also known as FURIN_HUMAN, FURIN, FUR, PACE, PCSK3. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) (PubMed:20489134, PubMed:21763278)., (Microbial infection) Cleaves and activates diphtheria toxin DT., (Microbial infection) Cleaves and activates anthrax toxin protective antigen (PA)., (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin., (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP., (Microbial infection) Facilitates human coronaviruses EMC and SARS-CoV-2 infections by proteolytically cleaving the spike protein at the monobasic S1/S2 cleavage site. This cleavage is essential for spike protein-mediated cell-cell fusion and entry into human lung cells., (Microbial infection) Facilitates mumps virus infection by proteolytically cleaving the viral fusion protein F. Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and connection to clathrin adapters (PubMed:11331585). Interacts with LAMP1, LAMP2 and LAMP3 (PubMed:32295904).

Also known as FURIN_HUMAN, FURIN, FUR, PACE, PCSK3. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:162 ...

EXTERNAL LINKS

FURIN

Mutations

Mutation(s) distribution

Mutations table