FEATURES

FAMILY

DESCRIPTION

Also known as SCTN1_SALTY, sctN1, invC, spaI, spaL. ATPase component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:15060043, PubMed:16208377, PubMed:26170413). Acts as a molecular motor to provide the energy that is required for the export of proteins (Probable). Required for type III secretion apparatus (T3SA) formation, proper protein secretion, host cell invasion and virulence (PubMed:8045880, PubMed:14762212, PubMed:15060043, PubMed:26170413). May play a critical role in T3SS substrate recognition, disassembly of the effector/chaperone complex and unfolding of the effector in an ATP-dependent manner prior to secretion (PubMed:16208377). Releases the effector protein SptP from the chaperone SicP in an ATP-dependent manner (PubMed:16208377). The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569, PubMed:28283062). This subunit is part of the cytosolic complex (PubMed:15060043, PubMed:31288030, PubMed:28283062). Forms homohexamers (PubMed:15060043, PubMed:28283062). Interacts directly with OrgB/SctL (stator protein) and InvI/SctO (stalk protein) (PubMed:15060043, PubMed:31288030, PubMed:28283062). Forms a complex with SpaO/SctQ and OrgB/SctL (PubMed:31288030). Interacts with the chaperone/effector protein complex SicP-SptP via its C terminus (PubMed:16208377). Interacts with the effector protein SopD (PubMed:20185511).

Also known as SCTN1_SALTY, sctN1, invC, spaI, spaL. ATPase component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eu ...

EXTERNAL LINKS

sctN1

SPI-1 type 3 secretion system ATPase

sctN1

Molecular Synopsis