FEATURES

FAMILY

DESCRIPTION

Also known as OPD_SPHSA, opd. Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate (By similarity). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

opd

Parathion hydrolase

opd

Molecular Synopsis