FEATURES

FAMILY

DESCRIPTION

Also known as LEXA_ECOLI, lexA, exrA, spr, tsl, umuA. Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352). Homodimer.

Also known as LEXA_ECOLI, lexA, exrA, spr, tsl, umuA. Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic s ...

EXTERNAL LINKS

lexA

LexA repressor

lexA

Molecular Synopsis