FEATURES

FAMILY

DESCRIPTION

Also known as PYRG_ECOLI, pyrG. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. Homodimer that associates to form homotetramer in the presence of ATP and UTP. The substrate nucleotides ATP and UTP act synergistically to promote oligomerization of CTPS from inactive dimers to active tetramers.

EXTERNAL LINKS

uniprot
enzyme classification

pyrG

CTP synthase

pyrG

Molecular Synopsis