FEATURES

FAMILY

Classic translation factor GTPase family

DESCRIPTION

Also known as RF3_ECOLI, prfC, miaD, tos. Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

EXTERNAL LINKS

uniprot
enzyme classification

prfC

Peptide chain release factor RF3

prfC

Molecular Synopsis