FEATURES

FAMILY

DESCRIPTION

Also known as TUSA_ECO57, tusA. Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin. Forms a heterotetramer with IscS. Certain pairs of proteins can bind simultaneously to IscS but TusA does not seem to be one of them. IscU can displace TusA from IscS.

EXTERNAL LINKS

tusA

Sulfur carrier protein TusA

tusA

Molecular Synopsis