rpoB (DNA-directed RNA polymerase subunit beta)

FEATURES

ORGANISM

Escherichia coli (strain K12)

FAMILY

DESCRIPTION

Also known as RPOB_ECOLI, rpoB, groN, nitB, rif, ron, stl, stv, tabD. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., Resistance to the antibiotics salinamide A, salinamide B, rifampicin, streptolydigin, CBR703, myxopyronin, and lipiarmycin can result from mutations in this protein. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

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EXTERNAL LINKS

rpoB

DNA-directed RNA polymerase subunit beta

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

rpoB

Molecular Synopsis