FEATURES

FAMILY

DESCRIPTION

Also known as ATDA_ECOLI, speG. Involved in the protection against polyamine toxicity by regulating their concentration (PubMed:7642535, PubMed:10986239). Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine (PubMed:8077207, PubMed:7052085, PubMed:6297970). It can also use spermine, but not putrescine (PubMed:7052085)., In addition, may act as a modulator of transcription through its ability to interact with the two-component response regulator RcsB. Inhibits transcription of the small RNA regulator rprA in an acetylation-independent manner. Interaction with the DNA-binding domain of RcsB might be responsible for SpeG-dependent inhibition of RcsB-dependent rprA transcription (PubMed:30562360). SpeG does not acetylate RcsB in vitro (PubMed:30562360). Homododecamer (PubMed:31205017). Ligand-free SpeG forms closed symmetric dodecamers in the crystal and open asymmetric dodecamers in solution (PubMed:31205017). In the absence of ligand, also exists in solution as hexamers and tetramers, but not dimers (PubMed:23908034, PubMed:8077207, PubMed:31205017). Can interact with the DNA-binding carboxyl domain of RcsB in the presence or absence of spermidine (PubMed:30562360).

EXTERNAL LINKS

speG

Spermidine N(1)-acetyltransferase

speG

Molecular Synopsis