FEATURES

FAMILY

DESCRIPTION

Also known as FABF_ECOLI, fabF, fabJ. Involved in the type II fatty acid elongation cycle (PubMed:9013860, PubMed:6988423). Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:9013860, PubMed:22017312). Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition (PubMed:9013860, PubMed:6988423). Can use acyl chains from C-6 to C-16 (PubMed:9013860, PubMed:22017312). Is able to catalyze the condensation reaction when CoA is the carrier for both substrates (PubMed:22017312). Homodimer.

EXTERNAL LINKS

fabF

Mutations

Mutation(s) distribution

Mutations table