FEATURES

FAMILY

DESCRIPTION

Also known as PPNN_ECOLI, ppnN, ygdH. Catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5-phosphate and the corresponding free base. Can use AMP, GMP, IMP, CMP, dTMP and UMP as substrates. Cannot catalyze the reverse reactions. Is required for optimal growth in glucose minimal medium, possibly because it contributes to nucleoside pool homeostasis by degrading excess nucleotides and feeding back the ribose moiety to catabolism.

EXTERNAL LINKS

uniprot
enzyme classification

ppnN

Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase

ppnN

Molecular Synopsis