FEATURES

FAMILY

membrane fusion protein (MFP) (TC 8.A.1) family

DESCRIPTION

Also known as ACRA_ECOLI, acrA, lir, mtcA. AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. Monomeric in solution. Homotrimeric; interacts independently with AcrB and TolC as well as AcrZ. Part of the AcrA-AcrB-TolC efflux pump. Complex assembly is independent of an efflux substrate and appears to be constitutive.

EXTERNAL LINKS

uniprot
enzyme classification

acrA

Structural Ligandability

Domains Chains

Distribution