FEATURES

FAMILY

DESCRIPTION

Also known as DSBA_ECOLI, dsbA, dsf, ppfA. Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.

EXTERNAL LINKS

uniprot
enzyme classification

dsbA

Thiol:disulfide interchange protein DsbA

Mutations

Mutation(s) distribution

Mutations table

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