FEATURES

FAMILY

nucleoside triphosphate pyrophosphohydrolase family

DESCRIPTION

Also known as MAZG_ECOLI, mazG. Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the type II MazE-MazF toxin-antitoxin (TA) system which mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA. Homodimer. Interacts with Era.

EXTERNAL LINKS

uniprot
enzyme classification

mazG

Nucleoside triphosphate pyrophosphohydrolase

mazG

Molecular Synopsis