FEATURES

FAMILY

alpha-ketoglutarate dehydrogenase family

DESCRIPTION

Also known as ODO1_ECOLI, sucA. E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Homodimer (PubMed:17367808). Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3) (Probable). Interacts (via N-terminus) with SucB, the E2 component of OGDH complex (PubMed:17367808).

EXTERNAL LINKS

sucA

Mutations

Mutation(s) distribution

Mutations table