FEATURES

FAMILY

DESCRIPTION

Also known as RFAH_ECO57, rfaH, hlyT, sfrB. Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains. Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).

EXTERNAL LINKS

uniprot
enzyme classification

rfaH

Transcription antitermination protein RfaH

rfaH

Molecular Synopsis