FEATURES

FAMILY

succinate/malate CoA ligase alpha subunit family

DESCRIPTION

Also known as SUCD_ECOLI, sucD. Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. Can use either ATP or GTP, but prefers ATP. It can also function in the other direction for anabolic purposes, and this may be particularly important for providing succinyl-CoA during anaerobic growth when the oxidative route from 2-oxoglutarate is severely repressed. Heterotetramer of two alpha and two beta subunits.

EXTERNAL LINKS

sucD

Mutations

Mutation(s) distribution

Mutations table