FEATURES

FAMILY

DESCRIPTION

Also known as SPEB_STRP1, speB. Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

speB

Structural Ligandability

Domains Chains

Distribution