FEATURES

FAMILY

DESCRIPTION

Also known as A1HB2_LOXIN, A1HB2. Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity). This toxin acts on sphingomyelin (SM) (PubMed:9790962). It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity). It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity). Induces hemolysis, dermonecrosis, vascular permeability and platelet aggregation (PubMed:9790962).

EXTERNAL LINKS

A1HB2

Mutations

Mutation(s) distribution

Mutations table