FEATURES

FAMILY

DESCRIPTION

Also known as VKT21_LYCMC, VKT21. Dual-function toxin that completely inhibits trypsin activity at a molar ratio of 1:1 (Ki=140 nM) and that inhibits mKv1.3/KCNA3 potassium channel currents (1 uM inhibits 50% of currents) (IC(50)=1.58 uM). Shows also weak inhibition on Kv1.1/KCNA1 (1 uM inhibits 25% of currents) and Kv1.2/KCNA2 (1 uM inhibits 25% of currents).

EXTERNAL LINKS

uniprot
enzyme classification

VKT21

Kunitz-type serine protease inhibitor LmKTT-1a

VKT21

Molecular Synopsis