FEATURES

FAMILY

DESCRIPTION

Also known as PA2B2_PROFL, PA2B2. Snake venom phospholipase A2 (PLA2) that shows anticoagulant activities, strong myolytic activity, infiltration of polymorphonuclear cells, and edema in stromal tissues. Induces cell death of Jurkat cells in a concentration-dependent manner. Shows a low phospholipase A2 activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Exists as a monomer in both solution and crystal states (PubMed:30787342). In the presence of SDS or probably in the presence of phospholipids, assembles to form SDS-resistant stable oligomers (PubMed:30787342).

EXTERNAL LINKS

uniprot
enzyme classification

PA2B2

Basic phospholipase A2 BP-II

PA2B2

Molecular Synopsis