FEATURES

FAMILY

DESCRIPTION

Also known as CA1A_CONTE, CA1A. Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits rat alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=3.5 nM), rat alpha-7/CHRNA7 (IC(50)=392 nM) nAChR, and the L.stagnalis soluble acetylcholine receptor (all tested without hydroxyproline).

EXTERNAL LINKS

uniprot
enzyme classification

CA1A

Alpha-conotoxin TxIA

Mutations

Mutation(s) distribution

Mutations table

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