FEATURES

FAMILY

DESCRIPTION

Also known as KPHAB_ACTTE, KPHAB. Voltage-gated potassium channel inhibitor that is certainly used for prey capture (PubMed:30109357). It inhibits several potassium channels, but not all (Kv1.1/KCNA1 (IC(50)=353 nM), Kv1.2/KCNA2 (IC(50)=146 nM), Kv1.3/KCNA3 (IC(50)=3051 nM), Kv1.6/KCNA6 (IC(50)=191 nM), and Shaker IR (23% inhibition at 3 uM)) (PubMed:30109357). In vivo, injection of this toxin into amphipods results in impaired swimming followed by contractile paralysis (PubMed:30109357).

EXTERNAL LINKS

uniprot
enzyme classification

KPHAB

Kappa-actitoxin-Ate1a

KPHAB

Molecular Synopsis