FEATURES

FAMILY

orthopneumovirus small hydrophobic protein family

DESCRIPTION

Also known as SH_HRSVA, SH, 1A. Viroporin that forms a homopentameric ion channel displaying low ion selectivity (PubMed:18369195, PubMed:22621926, PubMed:25100835, PubMed:27817112). May play a role in virus morphogenesis and pathogenicity at various stages of the viral life cycle. Accumulates at the membrane of the Golgi apparatus in infected cells and may facilitate virus release by modifying the secretory pathway (PubMed:15105532, PubMed:23229815). May enhance host membrane permeability and disrupt cellular ion homeostasis, which can be sensed as damage-associated molecular patterns/danger signals, triggering NLRP3 inflammasome activation and inflammatory immune response (PubMed:23229815). Also inhibits host TNFA-mediated signaling pathway and may delay apoptosis, allowing time for the virus to replicate (PubMed:17494063). Homopentamer forming a funnel-like pore (PubMed:18036342, PubMed:18369195, PubMed:22621926). Interacts with glycoprotein G; this interaction occurs on the surface of virion particles and infected cells (PubMed:18036342). Interacts with host BCAP31 (via C-terminus); this interaction is direct (PubMed:25854864).

Also known as SH_HRSVA, SH, 1A. Viroporin that forms a homopentameric ion channel displaying low ion selectivity (PubMed:18369195, PubMed:22621926, PubMed:25100835, PubMed:27817112). May play a r ...

EXTERNAL LINKS

SH

Mutations

Mutation(s) distribution

Mutations table