FEATURES

FAMILY

coronaviruses accessory protein 6 family

DESCRIPTION

Also known as NS6_SARS2, ORF6. Disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus. Thereby prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (PubMed:33097660). Suppresses IFN-beta production possibly by blocking IRF3 nuclear translocation (PubMed:32979938). Interacts with host KPNA2; this interaction may inhibit IFN-beta production by blocking IRF3 nuclear translocation (PubMed:32979938). Associates (via C-terminus) with the NUP98-RAE1 complex; this interaction disrupts the host nuclear import (PubMed:33097660). May interact with nsp8 (By similarity). Interacts with protein ORF9b (By similarity).

EXTERNAL LINKS

ORF6

ORF6 protein

ORF6

Molecular Synopsis