FEATURES

FAMILY

DESCRIPTION

Also known as ADX_HUMAN, FDX1, ADX. Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). Interacts with CYP11A1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FDX1

Adrenodoxin, mitochondrial

FDX1

Molecular Synopsis