FEATURES

DESCRIPTION

Also known as MYBB_HUMAN, MYBL2, BMYB. Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22. Interacts with CCNF (via the Cyclin N-terminal domain) (PubMed:25557911).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MYBL2

Myb-related protein B

MYBL2

Molecular Synopsis