FEATURES

FAMILY

DESCRIPTION

Also known as OSTP_HUMAN, SPP1, BNSP, OPN. Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction., Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. Ligand for integrin alpha-V/beta-3.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SPP1

Osteopontin

SPP1

Molecular Synopsis