FEATURES

FAMILY

DESCRIPTION

Also known as ACEK_ECOLI, aceK. Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.

EXTERNAL LINKS

uniprot
enzyme classification

aceK

Isocitrate dehydrogenase kinase/phosphatase

aceK

Molecular Synopsis