FEATURES

FAMILY

DESCRIPTION

Also known as SPIKE_CVMJH, S. attaches the virion to the cell membrane by interacting with host receptor, initiating the infection., mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes., Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis. Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.

EXTERNAL LINKS

S

Spike glycoprotein

S

Molecular Synopsis