FEATURES

FAMILY

glucose-6-phosphate dehydrogenase family

DESCRIPTION

Also known as G6PD_HUMAN, G6PD. Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. Homotetramer; dimer of dimers (PubMed:24769394, PubMed:10745013, PubMed:15858258). Interacts with SIRT2; the interaction is enhanced by H(2)O(2) treatment (PubMed:24769394).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

G6PD

Mutations

Mutation(s) distribution

Mutations table