FEATURES

FAMILY

Orn/Lys/Arg decarboxylase class-II family

DESCRIPTION

Also known as DCOR_HUMAN, ODC1. Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (Probable). Does not form a heterodimer with AZIN2 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ODC1

Ornithine decarboxylase

ODC1

Molecular Synopsis