FEATURES

FAMILY

DESCRIPTION

Also known as IMDH2_CRIGR, IMPDH2. Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Homotetramer (PubMed:8681386). Interacts with CLOCK; in a circadian manner. Interacts with ANKRD9; leading to its ubiquitination and degradation by the proteasome (By similarity).

EXTERNAL LINKS

IMPDH2

Inosine-5'-monophosphate dehydrogenase 2

IMPDH2

Molecular Synopsis