FEATURES

FAMILY

DESCRIPTION

Also known as SKI_HUMAN, SKI. May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SKI

Ski oncogene

SKI

Molecular Synopsis