FEATURES

FAMILY

DESCRIPTION

Also known as CAF20_YEAST, CAF20, CAF2, CAP20. Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1/TIF4631 and EAP1 for binding to eIF4E/TIF45 and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA. Binding affinity for eIF4E/TIF45 is 10-fold less than that of eIF4G1/TIF4631. Required for induction of pseudohyphal growth in response to nitrogen limitation, probably by regulating STE12 translation. Interacts with TIF45.

EXTERNAL LINKS

uniprot
enzyme classification

CAF20

Mutations

Mutation(s) distribution

Mutations table