FEATURES

FAMILY

DESCRIPTION

Also known as BIOD1_ECOLI, bioD1. Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7, 8-diaminopelargonic acid (DAPA, also called 7, 8-diammoniononanoate) to form a ureido ring. Only CTP can partially replace ATP while diaminobiotin is only 37% as effective as 7, 8-diaminopelargonic acid (PubMed:4892372, PubMed:4921568). In another study both CTP and GTP (but not ITP, TTP or UTP) can partially replace ATP (PubMed:25801336). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

bioD1

ATP-dependent dethiobiotin synthetase BioD 1

Mutations

Mutation(s) distribution

Mutations table

Search Mutation