FEATURES

DESCRIPTION

Also known as PIPA_DROME, norpA, PLC-beta. The production of the second messenger molecules diacylglycerol (DAG) and inositol 1, 4, 5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794). Interacts with inaD.

EXTERNAL LINKS

norpA

1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase

norpA

Molecular Synopsis