FEATURES

FAMILY

DESCRIPTION

Also known as DPOA_YEAST, POL1, CDC17. Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase (PubMed:10898792, PubMed:22119860, PubMed:31488849). POL1 has a role in promoting telomere replication during interaction with CDC13 (PubMed:10898792). DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A and B, and the DNA primase large and small subunits. Subunit B binds to subunit A (By similarity). POL1 interacts with CDC13, POB3, SPT16 and MCM10.

EXTERNAL LINKS

POL1

Mutations

Mutation(s) distribution

Mutations table