FEATURES

FAMILY

Classic translation factor GTPase family

DESCRIPTION

Also known as EF2_HUMAN, EEF2, EF2. Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9 (PubMed:19417104). Interacts with RBPMS2 (PubMed:25064856).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EEF2

Elongation factor 2

EEF2

Molecular Synopsis