FEATURES

FAMILY

DESCRIPTION

Also known as K1C10_HUMAN, KRT10, KPP. Plays a role in the establishment of the epidermal barrier on plantar skin., (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization., (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. Heterotetramer of two type I and two type II keratins. Heterodimer with KRT1 (PubMed:27595935). Two heterodimers of KRT1 and KRT10 form a heterotetramer (PubMed:27595935). The KRT10 subunit in the heterotetramer is probably disulfide-linked (Probable).

EXTERNAL LINKS

KRT10

Keratin, type I cytoskeletal 10

KRT10

Molecular Synopsis