FEATURES

DESCRIPTION

Also known as CD59_HUMAN, CD59, MIC11, MIN1, MIN2, MIN3, MSK21. Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase., The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. Interacts with T-cell surface antigen CD2.

Also known as CD59_HUMAN, CD59, MIC11, MIN1, MIN2, MIN3, MSK21. Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the as ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CD59

Mutations

Mutation(s) distribution

Mutations table