FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as DHB1_HUMAN, HSD17B1, E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1. Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH. Homodimer. Exists predominantly as an homodimer but also exits as monomer.

Also known as DHB1_HUMAN, HSD17B1, E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1. Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HSD17B1

17-beta-hydroxysteroid dehydrogenase type 1

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

HSD17B1

Structural Ligandability

Domains Chains

Distribution