FEATURES

FAMILY

DESCRIPTION

Also known as RL3_YEAST, RPL3, MAK8, TCM1. Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:24865971, PubMed:22096102). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:22096102). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:22096102). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uL3 plays a role in coordinating processes of accommodating the aminoacyl-tRNA in the PTC (PubMed:22096102). Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL3 forms together with ES39L one of the contact sites for the signal recognition particle that targets ribosomes to the endoplasmic reticulum membrane (PubMed:9559554, PubMed:24865971, PubMed:22096102).

Also known as RL3_YEAST, RPL3, MAK8, TCM1. Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:24865971, PubMed:22096102). T ...

EXTERNAL LINKS

RPL3

Mutations

Mutation(s) distribution

Mutations table