FEATURES

FAMILY

DESCRIPTION

Also known as DPOZ_YEAST, REV3, PSO1. Nonessential DNA polymerase. Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Translesion synthesis in S.cerevisiae may use a specialized DNA polymerase that is not required for other DNA replicative processes. Has a role in the bypass of abasic (AP) sites. Highly inefficient in incorporating nucleotides opposite the AP site, but efficiently extends from nucleotides, particularly an A, inserted opposite the lesion. Forms DNA polymerase zeta with REV7.

EXTERNAL LINKS

uniprot
enzyme classification

REV3

DNA polymerase zeta catalytic subunit

REV3

Molecular Synopsis