FEATURES

FAMILY

DESCRIPTION

Also known as CCNB1_HUMAN, CCNB1, CCNB. Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Interacts with CDK5RAP3 (PubMed:15790566). Interacts with RFPL4A and UBE2A (By similarity). Interacts with INCA1 (PubMed:21540187).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CCNB1

G2/mitotic-specific cyclin-B1

CCNB1

Molecular Synopsis