FEATURES

DESCRIPTION

Also known as MCRB_ECOLI, mcrB, rglB. Recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines) produced by a broad range of DNA methylases and appears to act against 5-methylcytosine preceded by a purine residue. Binds to DNA containing methylated cytosines; also binds to GTP. Isoform 33 kDa is less active than isoform 51 kDa and may play a role in regulating the activity of isoform 51 kDa by competing with it in DNA and protein binding abilities.

EXTERNAL LINKS

uniprot
enzyme classification

mcrB

5-methylcytosine-specific restriction enzyme B

mcrB

Molecular Synopsis